Product Description
The product of a highly successful course at Memorial Sloan-Kettering Cancer Center, this book provides a thorough grounding in cancer genetics, enabling the clinician to convey to patients and their families an understanding of the genetic nature of cancer and to provide them with accurate advice. The contributors provide ample coverage of the genetic indicators that predispose to cancer, the role of genomic alteration in the etiology of neoplasia, and the use of clues offered by chromosomal changes in cancer cells to help predict the course of the disease and the patient’s response to treatment. This collection will be invaluable to clinical oncologists, cancer researchers, geneticists, genetic counsellors, pediatricians, and internists.

Genetics in Clinical Oncology

Product Description
Incidence and mortality of atherosclerosis and coronary heart disease (CHD) vary considerably among races, populations and ethnic groups. Some individuals with low levels of risk factors succumb early to disease while many others with a high risk profile do not. CHD clusters in families and is manyfold increased in first degree relatives of persons with an early onset of the disease. Such studies provide compelling evidence of the high degree of heritability of CHD and its risk factors. This book consolidates the available evidence for the roles of genetics in atherosclerosis, its correlates and its sequelae. It presents and discusses the methodology currently used to elucidate the role of genetics. Separate parts focus on evidence of familial aggregation and ethnic variability of the disease and on monogenic and polygenic inheritance modes including all the recent findings and innovation. The book also contains chapters on the genetic aspects of vessel wall processes, such as early structural findings in histological studies and the variability of coronary anatomic patterns. Polymorphisms at the DNA level (RFLP) are detailed and reviewed. Directions for future research in the exciting and fast developing realm of genetic epidemiology are outlined and the major preventive and public health implications are discussed. Genetic Factors in Coronary Heart Disease provides a systematic review of findings, integrated to offer a comprehensive summary and stepping stone for future research. It will be of interest to investigators in atherosclerosis, genetics, epidemiology, biostatistics, cardiology and public health.

Genetic Factors in Coronary Heart Disease

Product Description
This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.

Genetic Epidemiology of Cancer

Product Description
Many mutations occur in a genome, from large-scale chromosomal rearrangements to small-scale point mutations. This range requires a variety of techniques to detect them, the suitability of each varying from gene to gene and laboratory to laboratory. This book covers the strategies behind, and methodologies of, mutation detection for the beginner.

Finding Mutations

Product Description
This book is concerned with advances in research on dystrophin, and how its absence gives rise to muscular dystrophy. It is the first book to address relationships between the molecular structure and function of dystrophin since the structure of the gene for this protein was elucidated in 1988. The volume covers recent advances in knowledge on the structure of both the dystrophin gene and its associated promoters, and on the protein itself. Functional interactions of dystrophin and its related proteins in the environment of the plasma membrane are a central feature of the book. Other aspects considered are the expression of the dystrophin complex in muscle, in the brain, and at the neuromuscular junction. The book concludes with discussions of muscle regeneration, gene therapy of Duchenne muscular dystrophy, and cellular approaches to the therapy of the disease.

Dystrophin: Gene, Protein and Cell Biology

Product Description
This book brings together leading research material to provide a timely and informative text, explaining the major findings on the genetic origins of the disease together with implementation of treatment

Cystic Fibrosis

Product Description
This bibliography contains references to material in the field of behavioral teratology–a hybrid between psychology, with its emphasis on behavior, and teratology, which emphasizes factors interfering with normal development. Abel includes entries published prior to 1985 that deal with the effects of prenatal exposure to drugs, environmental pollutants, x-rays, and other detrimental influences on behavior after birth. The entries are arranged first by type of agent and then alphabetically by author. Each item is numbered consecutively and is referred to by number in the Subject Index. An introduction provides background material on the field.

Behavioral Teratology: A Bibliography to the Study of Birth Defects of the Mind

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From reviews of previous volumes in the series: ‘Extremely valuable…thoroughly recommended.’–Annals of Human Genetics ‘The most lucid and stimulating discussions of the topic to be found anywhere.’–American Scientist

Advances in Human Genetics, Vol. 22

Product Description
National Cancer Institute, Bethesda, MD. Describes how to translate knowledge about a particular screening test into action and how to involve the person being considered for screening in the decision. Provides a practical approach to screening implementation for cancer sites. For students and physicians. Extended-outline format.

Cancer Screening: Theory and Practice

Product Description
Nutrition is one of the many factors that plays an important role in the intensity and duration of disease states. By studying the complex interactions of genes with specific nutrients, variations in symptoms can be understood. Nutrients and Gene Expression addresses a group of genetic conditions believed to develop as a result of nutrient-gene interactions including:

Nutrients and Gene Expression: Clinical Aspects