Product Description
Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Non-Myeloablative Allogeneic Transplantation will provide both practitioners and academic clinicians with a better understanding of underlying concepts, current methodologies, and results obtained by the pioneering centers for this rapidly evolving field.

Non-Myeloablative Allogeneic Transplantation

Product Description
Univ. Paul Sabatier, France. Summary of the main systems of blood group antigens and MHC molecules in nonhuman primates. Emphasis on the molecular structure of the gene products. 30 contributors, 14 U.S.

Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates: Primate Blood Group and MHC Antigens

Product Description
Blood coagulation and fibrinolysis has been traditionally classed as a part of hematology and the complement system as a part of immunology. An analysis of these two systems at a molecular level, however, has revealed some intriguing evolutionary relationships among some of the macromolecules involved. Evidently, there are similarities in the cascade of reactions that characterize the processes. It is therefore highly suitable that these topics are presented together in one volume. This book presents a thorough explanation and analysis of our current understanding of the proteins and enzymes involved in each of the three processes, and includes a section devoted to special topics of relevance, such as the kinin system, glycosylation, signal peptides, and the serpin family.

Mechanisms in Blood Coagulation, Fibrinolysis and the Complement System

Product Description
Sanofi, Paris, France. Gathers and evaluates the most relevant clinical studies on the therapeutic efficacy of low molecular weight heparins from 1985 to the present. Each study is presented on two pages, its main parameters described, and a table of results presented. Assists physicians in deciding where and how to use this therapy. Well referenced.

Low Molecular Weight Heparin Therapy: An Evaluation of Clinical Trials Evidence

Product Description
Liver-Directed Therapy for Primary and Metastatic Liver Tumors is a comprehensive examination of tumors of the liver. It provides a unique multi-modality approach to management of all types of primary and secondary liver tumors. The biology of liver cancers, state of the art radiologic imaging and novel, non-surgical interventional strategies are given. There is an in depth analysis of surgical options including transplantation, resection, interstitial ablation techniques and liver-directed chemotherapy for hepatocellular carcinoma, bile duct cancers, and colorectal and neuroendocrine liver metastases. Because of the unique and comprehensive examination of liver tumors, this work is an excellent resource for surgical, transplant and medical oncologists, surgeons, gastroenterologists, and radiologists.

Liver-Directed Therapy for Primary and Metastatic Liver Tumors

Product Description
This work provides a comprehensive review of the role of intravenous immunoglobulins in a wide range of immune-related diseases. Over 20 research workers from America and Europe together examine many important aspects of this subject and, in particular, assess the role of immunoglobulins in the treatment of asthma and allergy, autoimmune disorders, juvenile arthritis and recurrent pregnancy loss.

Immunomodulation by Intravenous Immunoglobulin

Product Description
This multidisciplinary overview covers basic concepts related to the discovery of the Hepatitis C virus, development of serological and nucleic acid tests to detect infection, the structure of the virus genome, generation of virus gene products, and proposed replication scheme. The volume discusses the epidemiology, transmission, pathogenesis of infection, the development of hepatocellular carcinoma associated with chronic virus infection, and current strategies for treatment. It also discusses advances in cell culture systems, animal models of infection, and emerging treatments and vaccine development.

Hepatitis C Virus: From Laboratory to Clinic

Product Description
Stem cell research holds great promise for therapeutic applications. This rapidly advancing field is the focus of the biennial international symposium and workshop whose proceedings are contained within this volume.

The major topics covered are stem cell function, including self-renewal, survival, migration, and regulation; the stem cell niche; stem cell fate as lineage commitment takes place; malignant hematopoiesis; hematopoiesis regulators; and embryonic stem cells and plasticity.

As with previous volumes in this unique series of proceedings, it is hoped that further cooperation and collaborative projects will be generated by disseminating these presentations widely.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Hematopoietic Stem Cells VI, The Annals of the New York Academy of Sciences

Product Description
Transfusion medicine is rapidly changing from what was a relatively narrowly focused field with a limited diagnostic and therapeutic scope to one that embraces fundamental elements of immunology, stem cell biology, the inflammatory response and hemostatis. This shift in focus is in response to the accelerated pace of advances in biomedical research. No longer constrained to diagnoses based on blood group serology or to therapies based on a limited number of blood components and derivatives, transfusion medicine is redefining itself through the clinical application of modern biotechniques.

In Emerging Technologies in Transfusion Medicine examples of the emerging technologies that are transforming both diagnostic and therapeutic aspects of the field are highlighted, offering a deeper understanding and an informed evaluation necessary for their application.

Highlights:

New approaches to screening donor blood for prions and bacteria
Use of phage display technology to develop new diagnostic tools or therapeutic agents
Use of a variety of molecular biological techniques
Potential application of gene array technology and proteomics
New therapeutic agents in transfusion medicine
Agents for intervening in a pathogenic process that is fundamental to transfusion medicine
Use of dendritic cells as immunotherapy agents
Advances in pathogen inactivation technology
Review of first-generation oxygen therapeutics and how this experience is influencing the next generation of candidate blood substitutes

Emerging Technologies in Transfusion Medicine

Product Description
Tightly organized into a super-condensed, outline-bulleted format, this handy, pocket-sized manual details precise, up-to-date information for diagnosis and treatment of lymphoma. Comprehensive and concise, the book covers epidemiology and guidelines for diagnosis and surgical, radiotherapeutic and chemotherapeutic treatment options. Throughout the handbook, tables and figures summarize important clinical data and current professional society recommendations, while salient references direct readers to additional information. Current, quick, and concise, for instant access on the ward or in the clinic!

Dx/Rx: Lymphoma