Product Description
The goal of this fascinating new book is to review the diversity of methods available to apply in situ hybridization histochemistry (ISHH) to a variety of experimental questions. This work includes topics such as synthesis and use of nick-translated DNA probes for ISHH, synthesis and use of oligomeric DNA probes for ISHH, and synthesis and use of RNA probes for ISHH. These interesting chapters describe the preparation of different radiolabeled probes for ISHH. They also discuss their respective advantages and limitations, and describe current results based on the use of these various probes. Sections of the text highlight low and high resolution autoradiography for ISHH, the use of biotin-labeled probes for ISHH, as well as the use of ISHH in combination with established anatomical techniques. In Situ Hybridization Histochemistry answers all of your questions regarding the quantification of ISHH. It also provides a practical description of typical protocols, both from molecular biology and histology. Investigators will understand and value this useful, powerful tool-whatever their backgrounds might be.

In Situ Hybridization Histochemistry

Product Description
The realisation that epithelial tissues are not simply passive barriers to the adsorption of materials into internal environments has brought about an enormous growth of investigation of mucosal functions and their active and passive protective roles. Epithelia are highly organized but complex structures, subserving numerous functions, including immunological defence. The use of pharmacological tools in these systems is increasing, which is improving our understanding of epithelial immunobiology. This volume adopts a step-by-step approach, whereby each chapter builds upon the previous one, progressively adding important foundation information, culminating in a series of chapters concerning particular epithelia, including respiratory, gastrointestinal, renal and ocular. The result is a comprehensive but integrated treatise of epithelial function and its immunopharmacology, which aims to serve as an appropriate starting point at which the clinical pulmonologist and the research scientist can obtain an appreciation of some aspects of epithelial immunopharmacology as they are currently understood.

Immunopharmacology of Epithelial Barriers

Product Description
This volume provides a timely and useful introduction to the theory and practical application of image analysis in histology. This powerful research technique can be used to detect not only stored products in a cell (immunocytochemistry) but the synthetic machinery and the genes that control it (in situ hybridisation), as well as the specific binding sites that act as receptors for a molecule following its release (in vitro autoradiography). The book provides a good introduction for beginners before looking in greater detail at more advanced material in selected areas. The volume highlights the importance of technique in gathering quantitative information. The book is divided into four sections: introductory material, image acquisition, image processing, and applications. The applications areas include quantitative immunochemistry, quantification of nerves and neurotransmitters and automated grain counting in in situ hybridisation histochemistry.

Image Analysis in Histology

Product Description
The study of metabolism is essential to an understanding of how diet and lifestyle affect our health. This clear introduction to human metabolism provides an overview of the relationship between metabolism and physiological processes in the human body and its role in health and disease. Beginning with a review of basic biochemistry in a human context, the text goes on to explore important metabolic variations between tissues, often ignored in introductory courses; this provides a strong basis from which students can develop an understanding of metabolic integration in the whole body. Part 1 reviews the major features of human metabolism and explains how metabolic pathways support basic cell functions. Part 2 describes the functions of the liver, adipose tissue, muscle, pancreas, intestine, the central nervous system, the blood and the kidneys and how these are supported by metabolism. Part 3 details the integration and control of metabolism in the whole body, and illustrates the ways in which this balance is disturbed by changes such as exercise, trauma, starvation and disease. This book will be of particular interest to advanced undergraduates studying metabolism and physiological biochemistry modules within degrees in Biochemistry, Biology, Biomedical Science, Physiology, and Medicine. It will also be a valuable reference guide for those in the pharmaceutical industry.

Human Metabolism

Product Description
This unique comprehensive volume in the Human Cell Culture Series encompasses research methodology for the growth and differentiation of all types of primary mesenchymal cells. Each of eleven mesenchymal cell types is covered by a leading expert in the field, providing insightful background information along with detailed current culture and assay techniques. Tissue types covered include bone, cartilage, tendons and ligaments, muscle (smooth, skeletal, and cardiac), adipose tissue, and skin (dermis), as well as multi-potent mesenchymal stem cells and fibrocytes. In addition to uses for research applications, current and future clinical applications of large-scale culture methods are also discussed. Further, the procurement and processing of primary human tissues is covered in detail. The generous inclusion of figures and tables, along with a consistent format, makes critical information highly accessible to the reader. Additionally, numerous literature citations provide a valuable reference for students and professionals in the fields of cell biology and bioengineering.

Human Cell Culture: Primary Mesenchymal Cells

Product Description
The classification represents an effort to bring together the variety of ways thymic epithelial neoplasms have been classified. It focuses on their growth characteristics, i.e. encapsulation and invasion, and cytoarchitectural features, e.g. spindle, epithelioid, and lymphocyte content. The classification, though restricted to the thymic region rather than the mediastinum in general, also covers neuroendocrine, germ cell, lymphoid, and stromal tumours, as well as tumour-like lesions and the neck tumours of thymic or related branchial pouch derivation.

Histological Typing of Tumours of the Thymus

Product Description
This second edition reflects the present stage of knowledge and advances in the histological typing of tumours of the central nervous system over the past 13 years since the first edition was published. The publication is intended to promote the adoption of a uniform terminology that will facilitate and improve communication among cancer workers.

Histological Typing of Tumours of the Central Nervous System

Product Description
This is the revised edition of the WHO histological classification of oesophageal and gastric tumours. It reflects the important changes that haveoccurred since the first edition in the fields of lymphomas, endocrine tumours and the dysplasias as well as adding a number of newly describedentities. it sets the international standard for the next decade.

Histological Typing of Oesophageal and Gastric Tumours: In Collaboration with Pathologists in 8 Countries

Product Description
Im Mittelpunkt dieser ersten umfassenden Darstellung der Geschichte der Histopathologie steht die Einführung des Mikroskops in der Krankheitsforschung und Diagnostik. Der Schwerpunkt liegt hier in der chirurgischen, gynäkologischen und dermatologischen Pathologie des 19.und 20. Jahrhunderts. Das Buch ist eine faszinierende Reise durch die Entwicklung an den verschiedenen Forschungsstätten im deutschen Sprachraum, aber auch in Frankreich, Großbritannien und den USA.

Geschichte der Histopathologie

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This book concerns the interpretation of mammograms. It contains 55 case-studies, each of which includes a full-size mammogram reproduction, a discussion of the case, additional mammograms and a histological correlation. The book is particularly aimed at specialists involved in screening for breast cancer and consultative mammography.

Film-Screen Mammography: An Atlas of Instructional Cases