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Book Description: Each book in the Myths & Facts series is written in clear and simple language by leading U.S. cancer specialists to dispel the many myths that surround cancer. Instead, this handbook offers solid insight about the disease and facts for individuals faced with a colorectal cancer diagnosis. The book is carefully illustrated and punctuated with patients’ comments. Readers will become familiar with the most current cancer screening and diagnostic techniques, treatment options, potential outcomes, support information, and more. Cancer patients, who are often asked to make quick decisions amid intense personal crises, will find the information needed to make rational decisions throughout the course of therapy. Ideal for patients and their families, doctor’s offices and waiting rooms, clinics, and libraries.

Myths & Facts About Colorectal Cancer, 2nd edition

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Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects

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Recent clinical trials of adjuvant therapy for gastric cancer in Japan have shown improved survival benefits, but the results have been considered controversial and have been viewed with some skepticism in the West. Until now, the efforts of Japanese surgical oncologists in multimodality therapy have not been fully understood because they have not been adequately reported in English. This volume now presents the experience and expertise of Japanese surgeons who utilize preoperative or intraoperative chemotherapy, or a combination of systemic and regional chemotherapy. Their collected work provides valuable insight in the Japanese perspective and success in treating gastric cancer. Included in the appendix is an extensive tabular analysis of the gastric cancer database at the Cancer Institute Hospital of Tokyo. Probably the largest such database in the world from a single institution, the analyses present the state of the art in treatment of gastric cancer.

Multimodality Therapy for Gastric Cancer: Appendix: Database of the Cancer Institute Hospital

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G. Landes). Rotterdam Cancer Institute, The Netherlands. Text emphasizing the bioreductively activated compounds that fall into the mitosene category, for investigators.

Mitosenes and Related Antitumor Drugs: Rational Design and Cytostatic Agents

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Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.

Microspheres and Regional Cancer Therapy

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This volume gives a general summary of the current understanding of lymphatic metastasis and the possibilities of more specific detection of lymph node metastasis. It describes in detail the procedure of sentinel lymph node detection in urogenital tumors, neck and thyroid tumors, malignant melanoma, gastric and colorectal cancer and tumors of the breast. The potential and limitations of this new method are discussed. This book provides comprehensive insight into a both clinically and scientifically important new field which is bringing about a marked improvement in the treatment of malignant tumors.

Lymphatic Metastasis and Sentinel Lymphonodectomy

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Intravascular brachytherapy is a specialty that demands an integrated approach from diverse disciplines. “Intravascular Brachytherapy: From Theory to Practice” sets out to ensure that all team members are speaking the same language; radiation oncologists are introduced to interventional cardiology and cardiologists are introduced to the terminology and implementation of radiation therapy. This book provides a comprehensive practical guide introducing the technique of intravascular brachytherapy and details the steps necessary to initiate an intravascular brachytherapy program in a hospital environment.

Intravascular Brachytherapy: From Theory to Practice

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In this volume, Drs. Rosenthal and Rotman have assembled a series of chapters authored by well recognized experts, with a unifying theme of exploring the scientific basis of chemotherapy and irradiation therapy. Clinical significant synergistic therapeutic interactions between chemotherapy and irradiation therapy are highlighted. The reader is provided with a concise and readily understandable overview of the theoretical and experimental basis for irradiation-chemotherapy interactions in the first chapter, co-authored by the editors. Subsequent chapters carefully address the pharmacokinetics of radiosensitizing agents, and explore the optimization of schedules for infusional therapy with concomitant radiation. Highlights of this volume include several chapters which provide useful overviews of the newest and most promising molecular approaches to cancer treatment: apoptosis as a target of therapeutic development; use of antiangiogenesis agents in cancer treatment; gene therapy and its applications to chemo-radiation therapy of cancer; and tumor suppression gene inactivation by SV40 mediated transformation.

Infusion Chemotherapy – Irradiation Interactions

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The rapid development of myocardial revascularization from angioplasty to stents, and now to new laser technology has meant that there is an abundance of information available which has not been distilled into a user-friendly format. Confusion exists as to where we are with angiogenesis: what can it do? how do we do it? what is acceptable as a satisfactory result? Drs Kornowski, Epstein and Leon answer the need for a concise reference on the subject. They have assembled a team of internationally-recognised experts who are at the forefront of research and clinical application on myocardial revascularization and angiogenesis. They examine direct, transmyocardial and percutaneous approaches to revascularization. In the latter part of the Handbook, there is discussion about growth factors protein and gene therapy which should serve as a guide and provide background facts so as to ensure greater informational access to the interventional cardiologist.

Handbook of Myocardial Revascularization and Angiogenesis

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Genetic Factors in Drug Therapy is the first comprehensive, in-depth survey of the current research on the genetic basis for the wide variety in people’s responses to drugs. Dr. Evans shows how understanding inherited differences in the rates at which people metabolize drugs and in their response to drugs in general leads to a clearer conception of–and can help to predict–adverse reactions to drugs, responses to the drug treatment of disease, and the occurrence of spontaneous disorders. New discoveries have allowed scientists to develop methods for direct genotyping of a person’s DNA, permitting them to predict with greater accuracy a given individual’s likely response to a course of drug treatment.

Genetic Factors in Drug Therapy: Clinical and Molecular Pharmacogenetics