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Experimental Therapeutics in Addiction Medicine contains the latest experimental research on innovative drug abuse treatments, including new medications and behavioral therapies for heroin and cocaine addictions. The editors present original experimental research on the effectiveness of innovative treatments for heroin/opiate, cocaine, and methamphetamine addiction. Unlike much previous drug treatment research, the studies in this book use biological indicators of drug use, not just self-report measures. The validity of the studies’conclusions are strengthened by the inclusion of drug toxicologies to measure outcomes.

The 15 studies are a result of a nationwide treatment research initiative sponsored by the National Institute on Drug Abuse and come from 11 different states. The evaluations, most using rigorous experimental designs with random assignment, include investigations of promising pharmacological, psychosocial and behavioral therapies. The psychosocial and behavioral therapies included several innovative, theory-based intensive outpatient programs for cocaine and methamphetamine abusers; medical maintenance for stabilized methadone patients; acupuncture treatment for cocaine and crack abusers; and intensive counseling combined with contingency management for methadone patients.

All of the studies in Experimental Therapeutics in Addiction Medicine are scientifically rigorous, with most using true experimental designs, and all emphasize treatment outcomes for patients. The reader will learn which treatments were effective and which remain promising, as well as which did not work as expected. The book also offers new research on special issues in clinical treatment. Both new pharmacological and psychosocial/behavioral treatment strategies are covered.

Clinicians–physicians, psychiatrists, psychologists, social workers, counselors, researchers–and other professionals involved in providing, supervising, administering, or studying substance abuse treatment can find important facts to help improve treatment outcomes for substance abusers. Administrators and policymakers can be assisted by this volume to develop more effective treatment programs and researchers can utilize the insights to help guide their future treatment research.

Experimental Therapeutics in Addiction Medicine

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Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours.
This book is the first to describe ADEPT in detail. Each chapter reviews an aspect of the immunology, enzymology, biochemistry, chemistry, and cancer chemotherapy which have been integrated into the ADEPT concept. An additional chapter describes the related approach of gene-directed enzyme prodrug therapy (GDEPT). This latter approach is still in its infancy but ADEPT has entered the clinic. The initial clinical studies with ADEPT are included and discussed in detail.

Enzyme-Prodrug Strategies for Cancer Therapy

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This book is an invaluable clinical reference for the therapeutic management of gastrointestinal and liver diseases which the gastroenterologist and trainee encounter in their practice. Various drugs and their interactions with their intended site and also with other drugs are discussed from a practical point of view. This book is not a treatise on gastrointestinal pharmacology but a practical guide to the therapeutic use of GI drugs.

Drug Therapy for Gastrointestinal Disease

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Because the delivery of precise quantities of drugs to specific sites on an optimal schedule is one of the most complex problems in clinical pharmacology and therapeutics today, Borchardt, Repta and Stella have striven to organize in this text a wide-ranging review of the subject. Coverage of nearly all of the key physical, chemical, and biological aspects of targeted drug delivery is provided by an internationally prominent cadre of authors, and includes treatment of: pharmacodynamics; pharmocokinetic factors; molecular mechanisms; therapeutic variables; receptors and delivery; “in vivo” electrochemistry; chromatographic analysis; microparticulate carriers; biodegradable systems; macromolecular systems; monoclonal antibody carriers; prodrugs; scintigraphy; physicochemical variables; the GI, blood-brain and dermal barriers.

Directed Drug Delivery: A Multidisciplinary Approach

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“Empowering women against breast cancer is my goal,” explains author, Dorothy Palmieri Doyle, a breast cancer survivor. This candid, moving story of her struggle to overcome the lethal threat of breast cancer is an uplifting example of the importance of self-education, assertiveness, and courage in times of crisis. Dancing On The Edge also serves as an excellent resource. It contains a bibliography, medical resources, and other valuables such as the National Association of Breast Cancer Organizations’ list of U.S. regional support groups.

Dancing on the Edge: A Story of Cancer, Courage and the Resurrection of Life

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Every two to three years the German Cancer Research Centre in Heidelberg publishes a report that describes the current status of cancer research in Germany. This monograph is written with oncologists, radiologists and biologists in mind.

Current Cancer Research 2002

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Modern therapeutic strategies in the last decade have radically changed the approach to the oncologic patient with metastatic disease. Not infrequently today metastases are managed more aggressively and addressed in a multidisciplinary way with extremely encouraging results in terms of both survival and disease control. There have been equally revolutionary changes in diagnostic imaging, with renewed attention to early diagnosis of both local and distant recurrence, in order to prompt timely radical intervention. The distribution of metastases is affected by characteristics of the primary improved survival of neoplastic patients and the routine imaging follow-up have resulted in greatly increased detection of metastatic malignancies with less than typical appearance and behaviour.

CT of Metastases

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Imaging techniques are often called upon in oncology in virtue of their essential role in tumor diagnosis, extension work up to various organs and detection of relapse. They are also indispensable in research and in clinical practice, allowing an objective assessment of tumoral regression in patients undergoing treatment. It is currently impossible to establish the management plan of a cancer patient or to obtain follow-up of such a patient under treatment without clinical and imaging confrontation.

CT and MRI in Oncology

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This volume discusses diagnostic and therapeutic strategies including current controversial issues in the management of gastrointestinal tumors. Special emphasis is given to rectal and pancreatic cancer. The first part presents the latest diagnostic developments for rectal cancer with a focus on the role of preoperative radiotherapy and radio-chemotherapy. Also considered is the surgical technique of total mesorectal excision. Recurrent rectal cancer is another important issue under discussion. A large section of the book is devoted to the diagnosis and interdisciplinary treatment of pancreatic cancer. Controversies regarding the role of adjuvant radiochemotherapy are presented in detail. The final part is dedicated to the treatment of liver metastases and describes the results of surgical resection and new therapeutic approaches such as in situ ablation and radiosurgery. This book offers an interdisciplinary perspective on gastrointestinal tumor therapy.

Controversies in Gastrointestinal Tumor Therapy: 6th International Symposium on Special Aspects of Radiotherapy, Berlin, September 5-7, 2002

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The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date examination of new developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including o inflammatory and immune reactions o scarring o neuron death o demyelination and remyelination o axonal regeneration o re-establishment of neuronal connectivity Providing a record of recent advances that will help point the way to future developments, this enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including: neurology, pharmacology, pathology, toxicology, immunology, and many others.

CNS Injuries: Cellular Responses and Pharmacological Strategies